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Table 5 Time to publication for interventional trials

From: Publication and non-publication of clinical trials in PTSD: an overview

Variable

Median survival time (95% CI)

Chi-square

p value

Overall

27 (24; 30)

  

Randomised

 

χ2(1) = 6.15

0.013*

 Yes

26 (23; 29)

  

 No

39 (32; 46)

  

Blinding

 

χ2(2) = 2.54

0.281

 Double blind

30 (24; 36)

  

 Single blind

24 (21; 27)

  

 Open label

23 (26; 40)

  

Intervention type

 

χ2(3) = 13.33

0.004*

 Drug

39 (28; 50)

  

 Behavioural

26 (23; 29)

  

 Procedure/device(e.g. TMS)

27 (24; 31)

  

 Drug and behavioural

20 (20; 34)

  

Any control condition used (e.g. waitlist, TAU)

 

χ2(1) = 5.35

0.021*

 Yes

26 (23; 29)

  

 No

39 (33; 45)

  

Placebo used

 

χ2(1) = 0.65

0.422

 Yes

30 (24; 37)

  

 No

27 (24; 30)

  

Comparator used

 

χ2(1) = 0.97

0.324

 Yes

27 (23; 31)

  

 No

29 (24; 34)

  

Number of study arms

 

χ2(2) = 6.75

0.034*

 One

44 (37; 52)

  

 Two

25 (22; 28)

  

 Three to six

30 (20; 40)

  

Any sponsor university

 

χ2(1) = 4.99

0.026*

 Yes

24 (20; 28)

  

 No

32 (26; 38)

  

Any sponsor hospital

 

χ2(1) = 0.08

0.776

 Yes

29 (21; 37)

  

 No

27 (24; 30)

  

Any sponsor governmental organisation

 

χ2(1) = 0.450

0.502

 Yes

28 (24; 32)

  

 No

26 (22; 30)

  

Any sponsor pharmaceutical/industry

 

χ2(1) = 2.896

0.086

 Yes

40 (0; 83)

  

 No

27 (24; 31)

  

Any sponsor non-commercial

 

χ2(1) = 0.90

0.344

 Yes

34 (23; 45)

  

 No

27 (24; 30)

  

Contact email provided

 

χ2(1) = 0.87

0.352

 Yes

26 (23; 29)

  

 No

29 (24; 34)

  

Are the results related to PTSD

 

χ2(1) = 0.26

0.613

 Yes

27 (23; 31)

  

 No

39 (1; 77)

  

PTSD-related outcome

 

χ2(3) = 1.80

0.615

 Primary

31 (22; 40)

  

 Secondary

26 (23; 29)

  

 Both primary and secondary

25 (19; 31)

  

Other (e.g. covariate, condition studied)

30 (22; 38)

  

Primary outcome measure/s

 

χ2(2) = 2.32

0.115

Positive

26 (23; 29)

  

 Null

31 (25; 37)

  

 Mixed

23 (14; 32)

  

Secondary outcome measure/s

 

χ2(2) = 1.50

0.473

Positive

25 (21; 29)

  

 Null

29 (22; 36)

  

 Mixed

24 (20; 28)

  

Registered before 2006

 

χ2(1) = 0.32

0.573

 Yes

31 (24; 39)

  

 No

27 (24; 30)

  

Study registered before started

 

χ2(1) = 1.07

0.302

 Yes

27 (23; 31)

  

 No

28 (24; 32)

  

Study registered before completed

 

χ2(1) = 4.22

0.040*

 Yes

28 (24; 32)

  

 No

35 (26; 44)

  
  1. *Significance set at p < 0.05