- Open Access
- Open Peer Review
Publishing descriptions of non-public clinical datasets: proposed guidance for researchers, repositories, editors and funding organisations
© The Author(s) 2016
- Received: 17 February 2016
- Accepted: 22 April 2016
- Published: 22 June 2016
Sharing of experimental clinical research data usually happens between individuals or research groups rather than via public repositories, in part due to the need to protect research participant privacy. This approach to data sharing makes it difficult to connect journal articles with their underlying datasets and is often insufficient for ensuring access to data in the long term. Voluntary data sharing services such as the Yale Open Data Access (YODA) and Clinical Study Data Request (CSDR) projects have increased accessibility to clinical datasets for secondary uses while protecting patient privacy and the legitimacy of secondary analyses but these resources are generally disconnected from journal articles—where researchers typically search for reliable information to inform future research. New scholarly journal and article types dedicated to increasing accessibility of research data have emerged in recent years and, in general, journals are developing stronger links with data repositories. There is a need for increased collaboration between journals, data repositories, researchers, funders, and voluntary data sharing services to increase the visibility and reliability of clinical research. Using the journal Scientific Data as a case study, we propose and show examples of changes to the format and peer-review process for journal articles to more robustly link them to data that are only available on request. We also propose additional features for data repositories to better accommodate non-public clinical datasets, including Data Use Agreements (DUAs).
- Journal Article
- Scientific Data
- Data Repository
- Open Access Journal
- Data Journal
Open access to research data that can be understood and reused by others is a means to further scientific progress and publish more reliable and reproducible research [1, 2]. However, clinical research data often include information that could potentially identify individuals, meaning datasets must be anonymised prior to being shared beyond the study for which the data were originally collected. Although guidelines and processes for anonymisation of clinical data exist [3, 4], publication of freely available clinical datasets (such as ) remains uncommon. As open access to clinical datasets is often unfeasible, a more felicitous and pragmatic approach may be needed.
Some clinical datasets may be made available on request from authors of journal articles or through the recent emergence of dedicated data request systems. However, as large amounts of clinical research can go unpublished [6, 7], and clinical trials unregistered , the discoverability of many clinical datasets is suboptimal. In this paper, we use the term “non-public clinical datasets” to mean datasets that have been generated through experimental clinical research, such as clinical trials, and which are not openly accessible, but are available on request. Clinical research involving surgical, disease-specific or epidemiologic cohort databases, and electronic health records, which can be continually updated and held by an institution, should not be excluded from data sharing but may require specific additional guidance not covered in this paper.
In consultation with relevant stakeholders representing pharmaceutical companies, research funders, researchers and data repository managers, the editors and publishers of the journal Scientific Data propose guidelines for linking peer-reviewed journal articles to non-public clinical datasets. Throughout this paper, Scientific Data is used as a case study of how these guidelines will work in practice and we also propose how similar approaches could be taken by other journals that consider manuscripts describing clinical or other data that cannot be publicly available.
Data repositories are recognised as essential for enabling reliable access to data underlying research in a number of life science disciplines. Their use is ingrained in the practices of some research communities and in the editorial policies of, for example, the Nature journals . Common repositories for non-public clinical data are less well established, however. We propose implementation of specific features in data repositories for the archival of non-public clinical datasets, to enable appropriate cross-linking of these datasets to scholarly journal articles.
Summary of recommendations
Clinical researchers and their sponsors
Be prepared to share experimental data with editors, peer reviewers and other researchers in accordance with journal policies
Apply the shortest possible embargoes on data
Develop mechanisms to host clinical research data, including:
○ Provide stable identifiers for metadata records about non-public dataset(s)
○ Implement Data Use Agreements (DUAs)
○ Implement a transparent system for requesting access to data and reviewing requests to access data
○ Allow access to data in a timely manner and include a proportionate review of the scientific rationale, without introducing unnecessary barriers
Clinical journal editors and publishers
Check compliance with their journal’s data sharing policies for every submission
For manuscripts based on secondary access to trial data (e.g. data the original trial sponsor has made available for further research), check the research is consistent with the DUA and purpose for which data access was granted or ask authors to attest that the submission is compliant with these conditions
Increase the visibility of clinical datasets to peer reviewers
Build relationships with repositories for non-public clinical datasets to support public archiving of metadata and data from clinical research
Introduce links to data, data sharing statements and transparency statements in published articles
Data journal editors and publishers
Develop data article formats (for example Scientific Data’s Data Descriptor) to permanently link articles to descriptions of non-public clinical datasets
All sponsors and funders of trials
Build partnerships with and between data sharing initiatives, trusted repositories, and peer-reviewed journals committed to data sharing
Apply the shortest possible embargoes on data and ensure that data access is subject to a proportionate review (e.g. of the scientific rationale and qualifications of the research team), without introducing unnecessary barriers
How do researchers currently access non-public clinical data?
Data sharing between researchers has traditionally occurred through direct contact between individuals and research groups . Many journals have policies that require authors to share data that support their results with other researchers on request, but enforcement of such policies varies between journals (for a summary of journal policy types and approaches see ). Journal policies that only require data to be “available on request” without also mandating data availability statements have been found to be less effective for ensuring data access for future researchers [11–14]. However, even clinical journals with strong and enforced policies on data access (such as the BMJ and PLOS Medicine), data about identifiable human subjects will usually not be in the public domain, due to the need to protect research participants’ privacy.
Alongside changes in journal policies, initiatives from other stakeholders (regulatory agencies, the pharmaceutical industry and research groups) in clinical research have begun to facilitate greater access to non-public clinical datasets. This includes the European Medicines Agency (EMA) which has committed to providing access to individual patient data (IPD) in the future .
When surveyed about their data sharing attitudes and behaviours, clinical researchers express concerns about inappropriate secondary analysis of their data and patient privacy . The Yale Open Data Access (YODA; http://yoda.yale.edu/) project and Clinical Study Data Request (CSDR; http://clinicalstudydatarequest.com) have since 2012 provided restricted access to non-public clinical datasets while addressing these two concerns. As of January 2016, CSDR listed more than 2800 clinical studies from 12 pharmaceutical companies, for which access to data could be requested. Researchers are also able to enquire about the availability of other non-listed studies. The project has been described as a success by its independent data access review panel , and 179 research proposals (data requests) were submitted between May 2013 and November 2015 (https://www.clinicalstudydatarequest.com/Metrics.aspx). As of March 2015 GlaxoSmithKline, one of the companies using CSDR, had received 99 requests (approximately four requests per month) to access data from the 1200 trials it had listed. The YODA Project has compiled data from more than 120 studies, representing two commercial data providers, and has received 39 requests (http://yoda.yale.edu/summary-data-inquiries-and-requests).
Connecting non-public clinical data with journals and repositories
With increasing numbers of open access repositories for research data for many scientific disciplines (http://www.nature.com/sdata/data-policies/repositories; http://www.re3data.org/), which provide persistent, citable links to datasets and metadata records, it is relatively easy to link journal articles to publicly accessible data. In the area of clinical trials, the concept of allowing secondary researchers to access the data is relatively new and so data are not yet widely shared. In addition, since non-public clinical datasets often have no permanent public record or identifier, links between these and the peer-reviewed literature are far less robust than links between public datasets and the literature. This could be addressed by developing both the data access policies of journals and the relationships of journals with data repositories that can archive non-public datasets. Increasing the visibility of such data could also be supported by a new type of journal article focused on describing non-public clinical datasets—particularly those that are previously unpublished. These new articles could be an adaptation of “data papers” that are already published in data journals. Data journals are a relatively new type of journal focused on data publication . Below we describe the benefits of this approach for researchers, as opposed to simply posting information about non-public datasets on a website or posting summary results of clinical trials in trial registration databases.
YODA and CSDR provide public information about clinical studies for which data are available on request. Some of these studies may not be described in journal articles, and for studies that are published, it may not be clear in the published article that the underlying data are available. Moreover, when planning a new research project or systematic review, medical researchers primarily rely on bibliographic databases (such as PubMed/MEDLINE, Scopus, Web of Science), individual journals and clinical trial registries to find information rather than these websites. Better links with journal articles, which are more visible due to indexing in bibliographic databases, might increase the visibility and use of data on request services.
Scientific Data (http://www.nature.com/scientificdata) from the Nature Publishing Group is one example of a data journal (see  for others). It is an open access journal for descriptions of scientifically valuable datasets, where data articles (termed Data Descriptors) are linked to their corresponding publicly available datasets. With non-public datasets journal articles need to link to persistent and citable metadata, a “stub” record or landing page, for a clinical dataset that is available on request. The landing page for a non-public clinical dataset should contain sufficient metadata to facilitate an understanding of what the dataset is, and importantly, the conditions that must be met for access to the data (see below). Data Descriptors (and other types of research-based article) linked to the citeable landing page could then be written by those who created the non-public clinical dataset, increasing the discoverability of the dataset and providing a means to obtain scholarly credit for generating and sharing the data.
As well as increasing discoverability of content through indexing in bibliographic databases open access journals, in particular, can help ensure content is highly visible through exposure to standard internet search engines such as Google.
Quality and peer review
Peer review is central to publishing research in journals. Publication of Data Descriptors at Scientific Data (and some other data journals) involves formal peer review by independently selected experts, of both the article describing the dataset(s) and the dataset itself. The peer-review process at Scientific Data focuses on (re)usability and data integrity, rather than on the perceived importance or impact of the data (http://www.nature.com/sdata/for-referees). However, systematic peer review of underlying data is not routine in traditional research journals.
Scientific Data’s publication process includes data curation by a dedicated Editor, in addition to peer reviewer checks. This process includes the creation of standardised, machine readable metadata for every Data Descriptor. This is intended to facilitate data discoverability and reuse by using controlled vocabulary terms to capture sample and subject provenance, and outline the experimental workflow. Datasets in curated, readily consumable formats should increase confidence in the delivered data formats, adding further value to the offerings of data journals. Use of subject-specific repositories, which tend to use community-accepted data formats and standards, and have standardised data curation processes, also increases the likelihood that archived data can be reused.
A role of journals is to ensure the permanence and integrity of the scientific record, for example, by maintaining persistent links between articles and datasets and placing copies of content in redundant archives. Web link decay or “link rot” is well documented, and even in the peer-reviewed literature, an estimated 20 % of articles published in 2012 already suffer from broken web links when regular websites or URLs are cited . This deterioration of referential integrity across corresponding data sources presents obstacles to replicating or re-analysing results underlying the scientific record. Publishers’ use of persistent identifiers for journal articles, Digital Object Identifiers (DOIs), helps ensure readers and future researchers can access content as publishers commit to keeping article links up-to-date using the DOI system. DOIs are increasingly being created for datasets and metadata records, via data repositories.
Links with data repositories
While the YODA Project and CSDR have succeeded in increasing access to clinical research data, their websites, and documents hosted therein are not citable and linkable in the same way as journal articles, and other research objects assigned DOIs. Furthermore, researchers and projects funded by organisations such as Cancer Research UK, Medical Research Council Clinical Trials Unit (MRC CTU)  and the Wellcome Trust may have well-managed non-public datasets available via local hosting, but these archives are unlikely to meet preservation, discoverability and linking standards of journals and publishers. Scientific Data, for example, works with trusted repositories to publish its Data Descriptors and supports data archiving policies and activities across the Nature journals . Scientific Data has established criteria for assessing public research data repositories (see below) and has so far approved more than 80 repositories (http://www.nature.com/sdata/data-policies/repositories; https://biosharing.org/collection/ScientificData). Other publishers and journals also list suggested or recommended repositories for authors including BMJ Open, PLOS, and BioMed Central.
Negative, incomplete or inconclusive trial data
While a number of journals exist that explicitly encourage negative or inclusive trials to be published (such as Trials, Journal of Negative Results in Biomedicine), a type of article designed to describe non-public clinical trial data—regardless of whether discussion or analysis of the data are available—might be further incentive for researchers and their sponsors to share data.
Alternative approaches to data sharing
Advantages and disadvantages of alternative approaches to data sharing
The ‘Beacon’ model
• A common web service allows researchers to discover data relevant to their research without the data holder storing the data outside the host institution
• Comparatively easy to implement
All those of share-on-request systems, including:
Being piloted by Global Alliance for Genomics and Health for genomics data https://genomicsandhealth.org/work-products-demonstration-projects/beacon-project-0
• Can improve discoverability of clinical datasets which cannot be openly shared
• Lack of data preservation guarantees
• No independent governance of data requests
• No common system for citing datasets
The ‘Federation’ model
• Separate, locally controlled data resources share a common index and data transfer protocols
• Improved data preservation over the Beacon model
• Data preservation relies on multiple partner nodes.
• Easier for institutions and ethical committees to accept because data holder does not give up control of the data to an independent repository
• No independent governance of data requests
• Terms for anonymous peer review of data, if permitted, would likely need to be negotiated with each node independently
• Linking with the literature possible if stable data identifiers are used across the whole network
The ‘Iron-safe’ model
• Data stored in a hardened, centralised resource and analysis conducted within the confines of the system
• Appropriate for highly sensitive data collected in the course of clinical care
• Access barriers may be prohibitive
Planned for 100,000 English Genomes system (http://www.genomicsengland.co.uk/the-100000-genomes-project/data/)
• Anonymous peer review of data generally impossible
• A centralised resource can, in principle, provide an independent system for vetting and providing access, helping avoid the creep of biasing access requirements like co-authorship
• Difficult to link data with literature in a robust manner, if the index of the data resource is also protected
Also, similar to the Clinical Study Data Request (CSDR) model
• Data export from the system is limited and tightly controlled
While these other models are not completely inconsistent with data publications, the involvement of journals and data journals in data sharing and publication additionally provides independent data quality evaluation, better preservation through dedicated independent repositories, and data access or request procedures that are more transparent and less susceptible to bias.
Additional considerations for journals and data repositories
Data repositories that host non-public clinical datasets which are linked to peer-reviewed articles need to provide the following additional services to those repositories hosting only publicly accessible data.
Data use agreements
An essential component for the secondary use of non-public clinical datasets is a data use agreement (DUA) between the data generator or repository and the secondary researcher(s). The purposes of DUAs include reducing risks to participants and other parties involved in the study and to ensure the scientific value of secondary analyses, which includes commitments to publishing secondary analyses in peer-reviewed journals .
Template DUAs are provided by the YODA Project and CSDR (https://www.clinicalstudydatarequest.com/Documents/DATA-SHARING-AGREEMENT.pdf). The Multi-regional Clinical Trials Center at Harvard University also provides a template DUA (http://mrctcenter.org/resources/?project=framework-for-data-sharing).
Recommending wording for DUAs is beyond the scope of these guidelines. However, the position of Scientific Data is that DUAs describing datasets intended for publication in journals dedicated to open science should support wider use by independent qualified researchers, including for competitive analysis, and that the authors agree to relinquish intellectual property claims stemming from the data. Mandatory requirements for co-authorship for data creators should be avoided.
Controlled access and governance
Data repositories that meet or potentially could meet the proposed requirements (in this article) for hosting non-public clinical trial data
Type of data hosted
Example of non-public clinical dataset
UK Data Service—ReShare
Requires account to request access to specific dataset
Requires account to request access to specific dataset
European Genome-phenome Archive (EGA)
Specific to each study, some data are open
database of Genotypes and Phenotypes (dbGaP)
Human genotype and phenotype data
Requires account to request access to specific dataset
Specific to each study, some data are open
Specific to each study, some data are open
National Database for Clinical Trials related to Mental Illness (NDCT)
NIH funded data on any aspect of human mental health [includes National Database for Autism Research (NDAR) and Research Domain Criteria Database (RDoCdb)]
Requires account to request access to specific dataset
National Addiction & HIV Data Archive Program (NAHDAP)
Drug addiction and HIV research data
Requires account to request access to specific dataset
Cancer Imaging Archive
Anatomical imaging of human cancer
Requires completion of a DUA, some data are open
Specific to each study, some data are open
Some concerns have been raised about the speed of data release and usability of data from “voluntary data-sharing portals”  such as YODA and CSDR, and, more broadly, clinical trial units are understandably concerned about costs of managing controlled access to data .
Repository metadata records (landing pages) for linking journal articles to non-public clinical data will share many characteristics with repository records for public datasets. Good practice for data citation (citing of datasets in the reference list/bibliography similar to citing papers) is for links to datasets to resolve to landing pages rather than the raw data files. Standards are emerging for the information that is essential and desirable to be included in landing pages . These standards consist of a dataset description comprising a dataset identifier, title and brief description, creator, publisher, and publication year. Landing pages should also include persistence/permanence information and licensing information for the data. We recommend that landing pages for non-public clinical datasets also include information detailing the access controls pertinent to the data. Examples of landing pages can be found at the UK Data Archive (e.g. http://dx.doi.org/10.5255/UKDA-SN-7612-2) and the European Genome-phenome Archive (e.g. https://www.ebi.ac.uk/ega/datasets/EGAD00000000001) and in Table 2. For clinical trials, where prospective trial registration is established as ethical research practice, we recommend unique trial identifiers be included on landing pages.
Landing pages for non-public datasets in trusted repositories (Table 2) can facilitate robust citation and linking of papers reporting reanalysis of data obtained on request. Papers reporting reanalysis of clinical data accessed via data request portals, including from YODA  and Project Data Sphere  have begun to be published, but can lack robust—citable—links to data sources. A reanalysis of shared clinical data should ideally cite, in the reference list, the paper reporting the primary analysis of the data, the landing page(s) of the dataset(s) themselves (where the data have persistent links, such as DOIs) and, if applicable any data papers describing the datasets. This helps provide credit and acknowledgement to all those involved in data acquisition, sharing and analysis. Data repositories are also increasingly able to add links to citing articles as they are published.
Additional repository assessment criteria
Taking the above issues into consideration, we propose additional criteria by which journals and publishers can assess repositories for hosting of non-public clinical datasets:
Provide stable identifiers for metadata records about non-public dataset(s)
Allow access to data with the minimum of restrictions needed to ensure protection of privacy and appropriateness of secondary analyses, codified in Data Use Agreements (DUAs)
Allow access to data in a timely manner
Provide support for users of data
Be independent of the study sponsors and principal investigators
Have a transparent and persistent system for requesting access to data and reviewing requests to access data
Provide relevant data analysis software environments where data are not permitted to be downloaded locally
Provide public access to the metadata of archived data for third party search and discovery functionalities
Be broadly supported and recognised within their scientific community
Ensure long-term persistence and preservation of datasets in their published form
Implement relevant, community-endorsed reporting requirements
Provide stable identifiers for submitted datasets
Allow public access to data without unnecessary restrictions
Since this working group was formed, at least one other group (Burton et al.) has proposed criteria for “data safe havens” in healthcare .
Repositories that could or may meet the current and additional requirements
Specialist trial data systems such as CSDR (and YODA) have indicated a willingness to listen to feedback from researchers and may evolve as data sharing progresses. As well as the potential for these repositories to develop to meet certain criteria, there are number of other general and specialist repositories that could or may meet the above criteria (Table 2), at least for specific types of clinical research.
There are also clinical data systems and “federations” associated with specific projects and some have played roles in disseminating data in specific communities. The ADNI portal is one such example (http://neuroinformatics.harvard.edu/gsp/loni). The group responsible for this portal have published a peer-reviewed article  describing and linking to non-public data in this resource.
Another Data Descriptor published at Scientific Data describes a non-public clinical dataset—of neuroimaging data from brain tumour patients—hosted at the UK Data Archive . The Synapse repository has, also, enabled secure access to patient self-reported clinical observation data collected through smartphone apps—that have subsequently been described in and linked to peer-reviewed publications . Scientific Data has developed bespoke workflows with Harvard Dataverse, UK Data Archive and Synpase to facilitate anonymous peer review of confidential datasets. Collaboration with the European Genome-phenome Archive (EGA) has also facilitated journal coordinated peer review of non-public human genome data .
Additional manuscript sections required
The format of published articles—data papers and traditional research articles—needs to be developed to accommodate links to non-public datasets.
Articles should include information about why the data are not publicly available (i.e. because they contain personally identifiable information) and describe the restrictions on accessing the dataset. They should also state if the data are subject to a DUA and where the DUA can be found—ideally, this should be hosted permanently with the landing page of the non-public dataset. In Scientific Data, the Usage Notes section would be appropriate for this information. Persistent links to landing pages should also be cited, in the same way public datasets are cited. Other journals, such as PLOS ONE, Genome Biology, Palgrave Communications, GigaScience and Royal Society Open Science are now routinely including dedicated article sections to describe and link to datasets supporting published articles—these could be adapted to meet these requirements.
Where Data Descriptors, and other articles, link to non-public clinical datasets, we recommend authors include in their articles a transparency declaration guaranteeing that their description of the dataset is an honest and accurate account. Transparency statements for regular journal articles, for other aspects of research integrity, have been implemented by the BMJ .
Research participant consent
Part of a journal’s role is to enforce relevant ethical expectations regarding consent. An important consideration is whether participants gave appropriate consent for data to be made available to secondary researchers in the future (if data are not fully anonymised ). Where informed consent for data sharing was obtained, consent should include scholarly publications (peer-reviewed articles) that describe or link to datasets.
What data should be available to secondary researchers?
Blank case report forms
Annotations of blank case report forms
Protocol (all versions)
Reporting and analysis plan
Clinical study report
While the scope of these guidelines potentially goes beyond clinical trials—including molecular data types—this list defined by CSDR is a reasonable guide. The IOM has also described the clinical research data types that are needed for reanalysis, which differs slightly from the CSDR list (Chapter 5, p. 112) . Standards for reusability for historic, non-public clinical datasets might need to be less stringent if data are only available in file formats that might not be optimised for reuse.
Who should have secondary access to data?
The consensus of regulators, industry sponsors and funders of clinical trials is for data access to be granted to suitably qualified researchers with a legitimate reanalysis proposal. A requirement of CSDR’s procedures is that a researcher with a degree in statistics or a related discipline should be part of the research team. The Independent Review Panel for CSDR had, as of February 2015, approved 71 requests and rejected or advised to resubmit 4 requests. The YODA Project’s approval committee assesses “basic information about the Principal Investigator, Key Personnel, and the project Research Proposal, including a scientific abstract and research methods” when reviewing data access requests .
Journal polices generally require data supporting submitted works must be accessible to peer reviewers and editors, and study sponsors should already be used to providing access to data supporting manuscripts submitted to major medical journals. These repository criteria and guidelines could make these processes more efficient if applied to clinical research journals. To publish Data Descriptors in Scientific Data, peer reviewers and editors must be given controlled access to supporting data for every article. The majority of journals operate single or double blind peer review, which means some reviewers or journals might require their anonymity to be maintained (public data repositories often support anonymous peer review, although there is increasing adoption of open peer review).
Peer review of non-public clinical datasets
Whether the access controls on the data are warranted and if enough information is provided on how to request access to the data
Whether the data are sufficiently well described to enable independent researchers to assess the reuse value of the dataset (to help ensure data requested are reused)
When to provide secondary access to data
The IOM has recommended embargoes of up to 18 months from study completion before clinical trialists are required to share data, although this has been criticised for being too long . The International Committee of Medical Journal Editors (ICMJE) in 2016 proposed a draft policy for its member journals requiring sharing of anonymised IPD within 6 months of publication . In a major epidemic, a long embargo on data access and reuse could be to the detriment of fighting disease. But a reasonable period for analysis—a right of first use—is acknowledged in most research communities. Any embargo on non-public clinical dataset(s) described in and linked to a journal article would have to have expired to comply with the recommendations in this article. In general we advocate no, or short, embargoes on data release wherever feasible.
In consultation with a working group (see Acknowledgements), Scientific Data is developing its editorial and peer-review processes and relationships with repositories to support publication of Data Descriptors for non-public clinical datasets as we receive relevant submissions. Other journals—data journals and traditional journals—may wish to consider these repository, linking and editorial policy proposals. Some members of our working group are also helping to identify interested research teams and relevant datasets that could be part of a publication pilot. Indeed, we need real data with which to develop more robust links between non-public datasets and journal articles. We strongly encourage others to contact the editors (email@example.com), to discuss proposals.
Thanks to the Working Group members, who attended a meeting in December in 2014 which identified many of the issues highlighted in this paper and who provided comments on earlier drafts of the paper:
Robert Frost, Policy Director, Medical Policy, GSK
Richard Lehman, on behalf of the Yale Open Data Access Project
Fiona Reddington, Head of Clinical and Population Research Funding, Cancer Research UK
Will Greenacre, Policy Officer, Wellcome Trust
Matthew Sydes, Senior Scientist and Statistician, MRC Clinical Trials Unit
John Gonzalez, Publications Director, AstraZeneca
Jay Bergeron, Director, Translational and Bioinformatics, Pfizer
Jessica Ritchie/Joseph Ross, Yale Open Data Access Project
Mark Hahnel, CEO and Founder, figshare
IH wrote the first draft of the original and revised manuscript. ALH drafted Table 1, and VK drafted Table 2. ALH created the figures. ALH, VK and SS were involved in the critical revision and development of the manuscript. All authors read and approved the final manuscript.
IH, VK and ALH are employees of Springer Nature, which publishes Scientific Data. SS is Honorary Academic Editor of Scientific Data.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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